Constitutive Activation of the Shaker Kv Channel
نویسندگان
چکیده
منابع مشابه
Constitutive Activation of the Shaker Kv Channel
In different types of K+ channels the primary activation gate is thought to reside near the intracellular entrance to the ion conduction pore. In the Shaker Kv channel the gate is closed at negative membrane voltages, but can be opened with membrane depolarization. In a previous study of the S6 activation gate in Shaker (Hackos, D.H., T.H. Chang, and K.J. Swartz. 2002. J. Gen. Physiol. 119:521-...
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An early component of the gating current in Shaker K+ channels with a time constant of approximately 12 microsec has been recorded with a high-speed patch-clamp setup. This fast component was found to be part of the gating current associated with the opening and closing of the channel. With regard to an energy-landscape interpretation of protein kinetics, the voltage and temperature dependence ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2003
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200308905